Recent Advances in Engineered Nanoparticles for RNAi-Mediated Crop Protection Against Insect Pests
نویسندگان
چکیده
Since the discovery of RNA interference (RNAi) in nematode worm Caenorhabditis elegans 1998 by Fire and Mello et al., strides have been made exploiting RNAi for therapeutic applications more recently highly selective insect pest control. Although triggering mRNA degradation insects through offers significant opportunities crop protection, application environmental naked dsRNA is often ineffective eliciting a response that results lethality. There are many possible reasons failed or weak induction RNAi, with predominant causes being formulated pesticide, field once ingested, poor cuticular oral uptake nucleic acid sometimes lack an innate strong systemic response. Therefore, last 10 years research effort has focused on developing methods protection delivery to enable RNAi-induced This review focuses design synthesis vectors (vehicles capable carrying protecting dsRNA) successfully enhance via machinery. The majority solutions exploit ability charged polymers, both synthetic natural, complex dsRNA, but alternative nanocarriers such as clay nanosheets liposomal vesicles also developed. various challenges obstacles development well-designed nanoparticles act protect highlighted. In addition, future directions improving efficacy RNA-mediated anticipated inspiration taken from polymeric architectures constructed RNA-based applications.
منابع مشابه
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ژورنال
عنوان ژورنال: Frontiers in agronomy
سال: 2021
ISSN: ['2673-3218']
DOI: https://doi.org/10.3389/fagro.2021.652981